From workplace to home environment: spreading of mouse allergens by laboratory animal workers,International Archives of Occupational and Environmental Health

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From workplace to home environment: spreading of mouse allergens by laboratory animal workers
International Archives of Occupational and Environmental Health ( IF 3 ) Pub Date : 2020-11-21 , DOI: 10.1007/s00420-020-01603-9
Hannah Kube _{1,

2} , Ronald Herrera _{1,

2} , Gisela Dietrich-Gümperlein _{1,

2} , Rudolf Schierl _{1,

2} , Dennis Nowak _{1,

2} , Katja Radon _{1,

2} , Laura Wengenroth _{1,

2} , Jessica Gerlich _{1,

2}

Affiliation

Purpose

Laboratory animal workers (LAW) working with laboratory mice are exposed to mouse allergens (MA). If MA are spread to home environments, this might increase the risk for allergies in LAW and their families. This study aimed to assess 1. whether spreading of MA from workplace to home environment takes place; 2. which factors increase spreading of MA.

Methods

In a cross-sectional study, dust samples were taken on the mattress and seating in homes of LAW (n = 105) and an unexposed comparison group (n = 13). From 89 LAW, additional dust samples were taken from their workplaces. Samples were analysed using Mus m1 ELISA kits [detection limit (DL) 0.2 ng mus m1/ml]. Sociodemographic data, personal history of allergies and cleaning habits, as well as work-related characteristics (LAW only) were assessed by questionnaire. Latent factors were assessed via factor analysis. Tobit models were fitted to analyse the latent factors’ contribution to MA spreading.

Results

MA concentration on the seating was significantly higher in home environments of LAW (median = 1.28 ng mus m1/m²) than in the comparison group (median < DL, p = 0.019). The highest workplace MA concentration was found on the floor of the scullery (median = 140,000.00 ng mus m1/m²), followed by hair-covering caps (median = 76.02 ng mus m1/m²). Cage and mouse facility cleaning tasks and infrequent changing of bed linen at home were statistically significantly associated with higher MA concentrations at home.

Conclusions

Spreading of MA from LAW’s workplace to their home environment takes place, especially among LAWs involved in cleaning tasks.

中文翻译：

从工作场所到家庭环境：实验动物工作人员传播小鼠过敏原

目的

与实验室小鼠一起工作的实验室动物工作者 (LAW) 会接触到小鼠过敏原 (MA)。如果 MA 传播到家庭环境，这可能会增加 LAW 及其家人过敏的风险。本研究旨在评估 1. MA 是否从工作场所传播到家庭环境；2. 哪些因素会增加 MA 的传播。

方法

在一项横断面研究中，在 LAW ( n = 105) 和未暴露的对照组 ( n = 13)的床垫和座椅上采集了灰尘样本。从 89 LAW 开始，从他们的工作场所采集了额外的灰尘样本。使用 Mus m1 ELISA 试剂盒 [检测限 (DL) 0.2 ng mus m1/ml] 分析样品。社会人口学数据、个人过敏史和清洁习惯，以及与工作相关的特征（仅限法律）通过问卷进行评估。通过因素分析评估潜在因素。拟合 Tobit 模型来分析潜在因素对 MA 传播的贡献。

结果

在 LAW 的家庭环境中，座椅上的 MA 浓度（中值 = 1.28 ng mus m1/m ²）显着高于对照组（中值 < DL，p = 0.019）。工作场所 MA 浓度最高的是洗碗间的地板（中位数 = 140,000.00 ng mus m1/m ²），其次是覆盖头发的帽子（中位数 = 76.02 ng mus m1/m ²）。笼子和老鼠设施的清洁任务以及不经常更换家中的床单与家中较高的 MA 浓度在统计学上显着相关。