This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose (Gal)-induced aging mice. Results showed that HCE possessed significantly higher calories and contents of valine and total phenols than CE; it also contained significant amounts of ferulic acid, sesamin, and sesamolin. HCE significantly decreased MDA and NO levels in serum and liver and increased liver GSH levels in the D-Gal-induced mice. HCE greatly enhanced SOD and CAT activities in serum and liver, and liver GPx activity, as well as upregulating SIRT1 expression and downregulating TNF-α, IL-1β, IL-6, iNOS, Cox-2, and MCP-1 expression in liver tissues. This study demonstrates that HCE was effective in suppressing the aging process through enhancing antioxidant and anti-inflammatory activities and modulating the aging-related gene expression.

本研究旨在研究用 2000 年制备的鸡精 (CE) 的化学和抗衰老特性。芝麻、当归， 和生姜(HCE)。分析 HCE 的营养和植物化学成分，并研究其对 D-半乳糖 (Gal) 诱导的衰老小鼠的抗衰老作用。结果表明，HCE的热量、缬氨酸和总酚含量显着高于CE；它还含有大量的阿魏酸、芝麻素和芝麻素。在 D-Gal 诱导的小鼠中，HCE 显着降低了血清和肝脏中的 MDA 和 NO 水平，并增加了肝脏 GSH 水平。HCE 显着增强血清和肝脏中 SOD 和 CAT 活性，以及​​肝脏 GPx 活性，并上调 SIRT1 表达，下调 TNF-α、IL-1β、IL-6、iNOS、Cox-2 和 MCP-1 在肝脏中的表达组织。