DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification,Neuropathology and Applied Neurobiology

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DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2023-02-26 , DOI: 10.1111/nan.12894
Thomas J Stone _{1,

2} , Kshitij Mankad ₃ , Ai Peng Tan _{4,

5} , Wajanat Jan ₆ , Jessica C Pickles _{1,

2} , Maria Gogou ₇ , Jane Chalker ₈ , Iwona Slodkowska ₈ , Emily Pang ₈ , Mark Kristiansen ₉ , Gaganjit K Madhan ₉ , Leysa Forrest ₉ , Deborah Hughes ₁₀ , Eleni Koutroumanidou ₁₀ , Talisa Mistry ₂ , Olumide Ogunbiyi ₂ , Saira W Ahmed ₂ , J Helen Cross ₇ , Mike Hubank ₁₀ , Darren Hargrave _{1,

11} , Thomas S Jacques _{1,

2}

Affiliation

Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
Department of Diagnostic Radiology, National University of Singapore, 21 Lower Kent Ridge Road, 119077, Singapore.
A*STAR Research Entities (ARES), Singapore Institute for Clinical Sciences (SICS), Singapore.
Department of Imaging, Imperial College Healthcare NHS Trust, London, UK.
Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Specialist Integrated Haematology and Malignancy Diagnostic Service, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
UCL Genomics, Zayed Centre for Research into Rare Disease in Children, 20 Guilford Street, London, WC1N 1DZ, UK.
Centre for Molecular Pathology, Royal Marsden Hospital, London, SM2 5NG, UK.
Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.

Glioneuronal tumours (GNTs) are poorly distinguished by their histology and lack robust diagnostic indicators. Previously, we showed that common GNTs comprise two molecularly distinct groups, correlating poorly with histology. To refine diagnosis, we constructed a methylation-based model for GNT classification, subsequently evaluating standards for molecular stratification by methylation, histology and radiology.

中文翻译：

基于 DNA 甲基化的胶质神经元肿瘤分类与组织学和放射学协同作用以完善准确的分子分层

胶质神经元肿瘤 (GNT) 的组织学很难区分，并且缺乏可靠的诊断指标。以前，我们表明常见的 GNT 包含两个分子上不同的组，与组织学相关性差。为了改进诊断，我们构建了一个基于甲基化的 GNT 分类模型，随后通过甲基化、组织学和放射学评估分子分层标准。

更新日期：2023-02-26

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