Backgound Aims: This meta-analysis aims at summarizing the whole body of research on cell therapies for acute myocardial infarction (MI) in the mouse model to bring forward ongoing research in this field of regenerative medicine. Despite rather modest effects in clinical trials, pre-clinical studies continue to report beneficial effects of cardiac cell therapies for cardiac repair following acute ischemic injury. Results: The authors’ meta-analysis of data from 166 mouse studies comprising 257 experimental groups demonstrated a significant improvement in left ventricular ejection fraction of 10.21% after cell therapy compared with control animals. Subgroup analysis indicated that second-generation cell therapies such as cardiac progenitor cells and pluripotent stem cell derivatives had the highest therapeutic potential for minimizing myocardial damage post-MI. Conclusions: Whereas the vision of functional tissue replacement has been replaced by the concept of regional scar modulation in most of the investigated studies, rather basic methods for assessing cardiac function were most frequently used. Hence, future studies will highly benefit from integrating methods for assessment of regional wall properties to evolve a deeper understanding of how to modulate cardiac healing after acute MI.

背景 目的：本荟萃分析旨在总结小鼠模型中急性心肌梗死 (MI) 细胞疗法的整体研究，以推进再生医学领域正在进行的研究。尽管在临床试验中效果不大，但临床前研究继续报告心脏细胞疗法对急性缺血性损伤后心脏修复的有益作用。结果：作者对来自 257 个实验组的 166 项小鼠研究的数据进行的荟萃分析表明，与对照动物相比，细胞治疗后左心室射血分数显着提高 10.21%。亚组分析表明，心脏祖细胞、多能干细胞等二代细胞衍生物具有最大的治疗潜力，可以最大程度地减少 MI 后的心肌损伤。结论：尽管在大多数调查研究中功能性组织置换的概念已被局部瘢痕调制的概念所取代，但最常使用的是评估心脏功能的基本方法。因此，未来的研究将极大地受益于评估区域壁特性的整合方法，以加深对如何调节急性 MI 后心脏愈合的理解。