ABSTRACT

To analyze the value of the combined test of the cardiac color Doppler ultrasound, the serum middle receptor pro-atrial natriuretic peptide (MR-ProANP) and the N-terminal pro-brain natriuretic peptide (NT-ProBNP) in forecasting the hypertensive left ventricular hypertrophy (LVH) and left heart failure (LHF). All patients were subjected to cardiac color Doppler ultrasound examination to obtain left atrium volume index (LAVI), left ventricular end-diastolic diameter (LVEDD), early-diastolic peak flow velocity (E), early-diastolic mean flow velocity (e’), early-diastolic peak flow velocity/early-diastolic mean flow velocity (E/e’) and left ventricular ejection fraction (LVEF). Biomarkers were performed to obtain serum MR-ProANP and NT-ProBNP concentrations, and statistical analysis was performed. The LVEF was obviously lower than that in the control group (P<0.01). The area under the receiver operating characteristic (ROC) curve (AUC) values of LVEF, E/e’, serum MR-ProANP and NT-ProBNP alone were in the range of 0.7–0.8. The AUC, sensitivity and specificity of LVEF and E/e’ combined with MR-ProANP and NT-ProBNP to diagnose hypertensive LVH and LHF were 0.892, 89.14% and 78.21%, which were higher than those of single diagnosis. In the heart failure group, LVEF was negatively correlated with serum MR-ProANP and NT-ProBNP concentrations (P<0.05), and E/e’ was positively correlated with serum MR-ProANP and NT-ProBNP concentrations (P<0.05). Pump function and ventricular remodeling in patients with hypertensive LVH and LHF are closely related to serum MR-ProANP and NT-ProBNP levels. Combination of the two testing can improve the prediction and diagnostic efficacy of LHF.

摘要

分析心脏彩色多普勒超声、血清中间受体心房钠尿肽原体（MR-ProANP）和氨基末端脑钠肽原体（NT-ProBNP）联合检测预测高血压左心室的价值肥大 (LVH) 和左心衰竭 (LHF)。所有患者均行心脏彩色多普勒超声检查，获取左心房容积指数（LAVI）、左心室舒张末期内径（LVEDD）、舒张早期峰值流速（E）、舒张早期平均流速（e'） 、舒张早期峰值流速/舒张早期平均流速 (E/e') 和左心室射血分数 (LVEF)。进行生物标志物以获得血清 MR-ProANP 和 NT-ProBNP 浓度，并进行统计分析。P <0.01）。单独的 LVEF、E/e'、血清 MR-ProANP 和 NT-ProBNP 的接受者操作特征 (ROC) 曲线 (AUC) 值下的面积在 0.7–0.8 的范围内。LVEF和E/e'联合MR-ProANP和NT-ProBNP诊断高血压LVH和LHF的AUC、敏感性和特异性分别为0.892、89.14%和78.21%，均高于单一诊断。心力衰竭组LVEF与血清MR-ProANP、NT-ProBNP浓度呈负相关（P <0.05），E/e'与血清MR-ProANP、NT-ProBNP浓度呈正相关（P<0.05)。高血压 LV​​H 和 LHF 患者的泵功能和心室重构与血清 MR-ProANP 和 NT-ProBNP 水平密切相关。两者联合检测可提高 LHF 的预测和诊断效能。