Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.

中文翻译：

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老化的小胶质细胞

小胶质细胞是大脑的组织驻留巨噬细胞群，专门支持中枢神经系统环境并保护其免受内源性和外源性侵害。尽管如此，它们的功能会随着年龄的增长而下降，其方式仍有待完全阐明。鉴于小胶质细胞在神经退行性疾病中发挥的关键作用，更好地了解老化的小胶质细胞表型是设计更好的预防和治疗策略的必要先决条件。在这篇综述中，我们讨论了关于衰老中小胶质细胞的最新文献，比较了啮齿动物模型和人类受试者的发现。