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Gelatin Methacryloyl Hydrogel, from Standardization, Performance, to Biomedical Application
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-04-28 , DOI: 10.1002/adhm.202300395
Jing He 1 , Yuan Sun 1 , Qing Gao 1, 2 , Chanfan He 1 , Ke Yao 1 , Tongyao Wang 3, 4 , Mingjun Xie 1, 5 , Kang Yu 1 , Jing Nie 1 , Yuewei Chen 1 , Yong He 1, 2, 6
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-04-28 , DOI: 10.1002/adhm.202300395
Jing He 1 , Yuan Sun 1 , Qing Gao 1, 2 , Chanfan He 1 , Ke Yao 1 , Tongyao Wang 3, 4 , Mingjun Xie 1, 5 , Kang Yu 1 , Jing Nie 1 , Yuewei Chen 1 , Yong He 1, 2, 6
Affiliation
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Gelatin methacryloyl (GelMA), a photocurable hydrogel, is widely used in 3D culture, particularly in 3D bioprinting, due to its high biocompatibility, tunable physicochemical properties, and excellent formability. However, as the properties and performances of GelMA vary under different synthetic conditions, there is a lack of standardization, leading to conflicting results. In this study, a uniform standard is established to understand and enhance GelMA applications. First, the basic concept of GelMA and the density of the molecular network (DMN) are defined. Second, two properties, degrees of substitution and ratio of solid content, as the main measurable parameters determining the DMN are used. Third, the mechanisms and relationships between DMN and its performance in various applications in terms of porosity, viscosity, formability, mechanical strength, swelling, biodegradation, and cytocompatibility are theoretically explained. The main questions that are answered: what does performance mean, why is it important, how to optimize the basic parameters to improve the performance, and how to characterize it reasonably and accurately? Finally, it is hoped that this knowledge will eliminate the need for researchers to conduct tedious and repetitive pre-experiments, enable easy communication for achievements between groups under the same standard, and fully explore the potential of the GelMA hydrogel.
中文翻译:
明胶甲基丙烯酰水凝胶,从标准化、性能到生物医学应用
甲基丙烯酰明胶 (GelMA) 是一种光固化水凝胶,由于其高生物相容性、可调节的理化性质和优异的成型性,广泛应用于 3D 培养,特别是 3D 生物打印。然而,由于GelMA的性质和性能在不同的合成条件下有所不同,因此缺乏标准化,导致结果相互矛盾。在本研究中,建立了统一标准来理解和增强 GelMA 应用。首先,定义了GelMA的基本概念和分子网络密度(DMN)。其次,使用取代度和固含量比这两个性质作为确定DMN的主要可测量参数。第三,从理论上解释了DMN及其在各种应用中的孔隙率、粘度、成型性、机械强度、膨胀、生物降解和细胞相容性方面的性能之间的机制和关系。回答的主要问题是:性能意味着什么,为什么重要,如何优化基本参数来提高性能,以及如何合理、准确地表征性能?最后,希望这些知识能够消除研究人员进行繁琐和重复的预实验的需要,使同一标准下的小组之间的成果能够轻松交流,并充分挖掘GelMA水凝胶的潜力。
更新日期:2023-04-28
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
明胶甲基丙烯酰水凝胶,从标准化、性能到生物医学应用
甲基丙烯酰明胶 (GelMA) 是一种光固化水凝胶,由于其高生物相容性、可调节的理化性质和优异的成型性,广泛应用于 3D 培养,特别是 3D 生物打印。然而,由于GelMA的性质和性能在不同的合成条件下有所不同,因此缺乏标准化,导致结果相互矛盾。在本研究中,建立了统一标准来理解和增强 GelMA 应用。首先,定义了GelMA的基本概念和分子网络密度(DMN)。其次,使用取代度和固含量比这两个性质作为确定DMN的主要可测量参数。第三,从理论上解释了DMN及其在各种应用中的孔隙率、粘度、成型性、机械强度、膨胀、生物降解和细胞相容性方面的性能之间的机制和关系。回答的主要问题是:性能意味着什么,为什么重要,如何优化基本参数来提高性能,以及如何合理、准确地表征性能?最后,希望这些知识能够消除研究人员进行繁琐和重复的预实验的需要,使同一标准下的小组之间的成果能够轻松交流,并充分挖掘GelMA水凝胶的潜力。