Experimental and neuroimaging studies suggest an influence of the time of day on acute infarct growth, but whether this could inform patient selection for acute treatments is uncertain. In a multicenter cohort of 9357 stroke patients undergoing endovascular treatment, morning treatment (05:00–10:59) was associated with lowest 90-day mRS scores (adjusted odds ratio, 1.27 [95% CI, 1.08–1.47]; p = 0.004). The association between successful recanalization and outcome was stronger in morning compared to evening-treated patients (p_ia = 0.046) with treatment benefit persisting until 24 h for morning-treated compared to 11.5 h for evening-treated patients suggesting that the time of day might inform patient selection for EVT.

中文翻译：

---

EVT 的时间与临床结果的关联以及中风后成功再通的益处

实验和神经影像学研究表明一天中的时间对急性梗塞生长有影响，但这是否可以为患者选择急性治疗提供依据尚不确定。在一项由 9357 名接受血管内治疗的卒中患者组成的多中心队列中，早晨治疗 (05:00–10:59) 与最低 90 天 mRS 评分相关（调整后的优势比，1.27 [95% CI, 1.08–1.47]；p  = 0.004）。与晚上治疗的患者相比，早上成功的再通与结果之间的关联更强（p _ia  = 0.046），早上治疗的患者的治疗益处持续到 24 小时，而晚上治疗的患者则持续到 11.5 小时，这表明一天中的时间可能告知患者选择 EVT。