The mechanisms of abdominal aortic aneurysm (AAA) formation and rupture are controversial in the literature. While the intraluminal thrombus (ILT) plays a crucial role in reducing oxygen flux to the tissue and therefore decreasing the aortic wall strength, other physiological parameters such as the vasa vasorum (VV) oxygen flow and its consumption contribute to altered oxygenation responses of the arterial tissue as well. The goal of this research is to analyse the importance of the aforementioned parameters on oxygen delivery to the aneurysmal wall in a patient-specific AAA. Numerical simulations of coupled blood flow and mass transport with varying levels of VV concentration and oxygen reaction rate coefficient are performed. The hypoperfusion of the adventitial VV and high oxygen consumption are observed to have critical effects on reducing aneurysmal tissue oxygen supply and can therefore exacerbate localized oxygen deprivation.

腹主动脉瘤（AAA）形成和破裂的机制在文献中存在争议。虽然管腔内血栓 (ILT) 在减少组织氧通量并因此降低主动脉壁强度方面发挥着至关重要的作用，但其他生理参数，例如血管滋养管 (VV) 氧流量及其消耗，会导致动脉氧合反应发生改变组织也是如此。本研究的目的是分析上述参数对患者特定 AAA 中动脉瘤壁氧气输送的重要性。对具有不同水平的VV浓度和氧反应速率系数的耦合血流和质量传递进行数值模拟。据观察，外膜VV灌注不足和高耗氧量对减少动脉瘤组织的氧供应具有关键影响，因此会加剧局部缺氧。