Crystalline porous materials are increasingly significant in synthetic and materials chemistry. Nonetheless, their broad industrial deployment is hampered by challenges in stability, production cost, scalability, and regenerability. Herein, we introduce a one-pot synthetic methodology for fabricating macrocycle-based hydrogen-bonded organic frameworks utilizing commercially available materials. Notably, mHOF-SYSU101, as a distinguished exemplar, can be synthesized on a multigram scale with near-quantitative yield from raw materials of merely 70% purity, underscoring its substantial cost-efficiency. mHOF-SYSU101 demonstrates extraordinary thermal stability up to 400 °C, and exhibits remarkable chemical resilience under complex and harsh conditions over a week. This sustained stability is attributed to the strategic integration of hydrophobic methyl groups that insulate hydrogen bonds from polar molecules, coupled with multiple noncovalent interactions within its architecture. Leveraging its intrinsic one-dimensional hydrophobic channels and hydrophilic surfaces, mHOF-SYSU101 achieves a remarkable 99% adsorption of iodine from seawater in just 2 min and maintains this fully reversible adsorption capacity over five cycles, showing great practical utility for the nuclear power industry. Moreover, mHOF-SYSU101 can be regenerated by introducing its trifluoroacetic acid solution into dimethyl sulfoxide or methanol, endowing mHOF-SYSU101 with unprecedented processibility and recyclability. This study paves new pathways for achieving the industrial application of crystalline porous materials.

结晶多孔材料在合成和材料化学中越来越重要。尽管如此，它们的广泛工业部署受到稳定性、生产成本、可扩展性和可再生性方面挑战的阻碍。在这里，我们介绍了一种利用市售材料制造基于大环的氢键有机骨架的一锅合成方法。尤其， mHOF-SYSU101作为一个杰出的范例，它可以用纯度仅为 70% 的原材料以几克规模合成，收率接近定量，凸显了其巨大的成本效益。 mHOF-SYSU101在高达 400°C 的温度下表现出非凡的热稳定性，并在复杂和恶劣的条件下表现出卓越的化学弹性一周。这种持续的稳定性归因于疏水性甲基的战略整合，该疏水性甲基将氢键与极性分子隔离，再加上其结构内的多种非共价相互作用。利用其固有的一维疏水通道和亲水表面， mHOF-SYSU101只需 2 分钟即可实现对海水中碘的 99% 吸附，并在五个周期内保持这种完全可逆的吸附能力，在核电工业中显示出巨大的实用性。而且， mHOF-SYSU101将其三氟乙酸溶液引入二甲亚砜或甲醇中可再生，赋予 mHOF-SYSU101具有前所未有的可加工性和可回收性。该研究为实现结晶多孔材料的工业应用铺平了新的途径。