A dual-localized DNAzyme walker (dlDW) was constructed by utilizing multiple split DNAzymes with probes, and their substrates are separately localized on streptavidin and AuNPs, serving as walking pedals and tracks, respectively. Based on dlDW, biosensing platform was successfully constructed and showed great potential application in clinical disease diagnosis.

中文翻译：

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基于链霉亲和素的双定位 DNAzyme walker 的构建，用于疾病生物标志物检测


利用带有探针的多个分裂DNA酶构建了双定位DNA酶步行器（dlDW），其底物分别定位在链霉亲和素和AuNP上，分别充当步行踏板和轨道。基于dlDW的生物传感平台成功构建，在临床疾病诊断中展现出巨大的应用潜力。