The immobilisation of artificial metalloenzymes (ArMs) holds promise for the implementation of new biocatalytic reactions. We present the synthesis of cross-linked artificial metalloenzyme aggregates (CLArMAs) with excellent recyclability, as an alternative to carrier-based immobilisation strategies. Furthermore, iron-siderophore supramolecular anchoring facilitates redox-triggered cofactor release, enabling CLArMAs to be recharged with alternative cofactors for diverse selectivity.

中文翻译：

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锚定在交联人造金属酶聚集体中的氧化还原可逆铁载体催化剂能够实现对映选择性转换

人工金属酶（ArM）的固定化有望实现新的生物催化反应。我们提出了具有优异可回收性的交联人工金属酶聚集体（CLArMA）的合成，作为基于载体的固定化策略的替代方案。此外，铁铁载体超分子锚定促进氧化还原触发的辅因子释放，使 CLArMA 能够用替代辅因子重新充电，以实现不同的选择性。