Airborne nanoplastics can enter alveolar cells and trigger intracellular oxidative stress primarily. Herein, taking advantage of the high electrochemical resolution of SiC@Pt nanoelectrodes, we achieved the quantitative discrimination of the major ROS/RNS within A549 cells, disclosed the sources of their precursors, and observed that the NO (RNS precursor) level significantly increased, whereas O₂˙⁻ (ROS precursor) remained relatively stable during the nanoplastics exposure. This establishes that iNOS or mitochondrion-targeted treatment may be a preventive or therapeutic strategy for nanoplastic-induced lung injury.

中文翻译：

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纳米塑料暴露诱导的细胞内活性氧和氮物种的纳米电化学监测

空气中的纳米塑料可以进入肺泡细胞并主要引发细胞内氧化应激。在此，利用SiC@Pt纳米电极的高电化学分辨率，我们实现了A549细胞内主要ROS/RNS的定量区分，公开了其前体的来源，并观察到NO（RNS前体）水平显着增加，而 O ₂ ˙ ⁻（ROS 前体）在纳米塑料暴露过程中保持相对稳定。这表明 iNOS 或线粒体靶向治疗可能是纳米塑料引起的肺损伤的预防或治疗策略。