Drug delivery systems based on natural carriers have recently gained considerable interest. However, rapid gastric emptying makes it difficult for drugs to remain in the stomach, and the complex modification or loading processes limit their advantages. Inspired by algal bloom characteristics, we designed a microalgae-based natural floating biosystem as a gastric drug delivery system for the treatment of alcohol-induced diseases. With the buoyancy of Spirulina platensis and the adhesion of bismuth pectin, the resveratrol can float in simulated gastric fluid for longer retention and be released rapidly upon contact with alcohol. In both mouse and piglet models, most of the floating biosystem can be retained in the stomach and effectively alleviate the inflammatory damage caused by alcohol with minimal toxicity. This biosystem can be quickly prepared by a simple mixing approach, which does not affect the bioactivity of microalgae, is suitable for large-scale production, and has potential for clinical practice.

基于天然载体的药物递送系统最近引起了相当大的兴趣。然而，快速的胃排空使得药物很难保留在胃中，复杂的修饰或装载过程限制了它们的优势。受藻华特征的启发，我们设计了一种基于微藻的天然漂浮生物系统，作为胃部药物输送系统，用于治疗酒精引起的疾病。借助钝顶螺旋藻的浮力和果胶铋的粘附作用，白藜芦醇可以漂浮在模拟胃液中，停留时间更长，与酒精接触后迅速释放。在小鼠和仔猪模型中，大部分漂浮生物系统可以保留在胃中，并以最小的毒性有效减轻酒精引起的炎症损伤。该生物系统可以通过简单的混合方式快速制备，不影响微藻的生物活性，适合大规模生产，具有临床应用潜力。