Janus structure plays a crucial role in achieving chemically driven nanomotors with exceptional motion performance. However, Janus‐structured chemically driven nanomotors with magnetic responsiveness are commonly fabricated by sputtering metal films. In the study, a self‐assembly technique is employed to asymmetrically modify the surfaces of magnetic silica (SiO2@Fe3O4) nanoparticles with platinum nanoparticles, resulting in the formation of this kind nanomotors. Compared to platinum film, platinum nanoparticles exhibit a larger surface area and a higher catalytic activity. Hence, the nanomotors demonstrate improved diffusion capabilities at a significantly lower concentration (0.05%) of hydrogen peroxide (H2O2). Meanwhile, exosomes have gained attention as a potential tool for the efficient delivery of biological therapeutic drugs due to their biocompatibility. However, the clinical applications of exosomes are limited by their restricted tropism. The previously obtained nanomotors are utilized to deliver exosomes, greatly enhancing its targetability. The drug doxorubicin (DOX) is subsequently encapsulated within exosomes, acting as a representative drug model. Under the conditions of H2O2 concentration at the tumor site, the exosomes exhibited a significantly enhanced rate of entry into the breast cancer cells. The utilization of the nanomotors for exosomes presents a novel approach in the development of hybrid chemically and magnetically responsive nanomotors.

中文翻译：

---

具有磁响应功能的化学动力纳米马达用于外泌体的靶向递送


Janus结构在实现具有卓越运动性能的化学驱动纳米电机方面发挥着至关重要的作用。然而，具有磁响应性的Janus结构化学驱动纳米电机通常是通过溅射金属薄膜来制造的。在该研究中，采用自组装技术用铂纳米粒子对磁性二氧化硅（SiO2@Fe3O4）纳米粒子的表面进行不对称修饰，从而形成这种纳米电机。与铂薄膜相比，铂纳米粒子表现出更大的表面积和更高的催化活性。因此，纳米电机在过氧化氢 (H2O2) 浓度显着降低 (0.05%) 的情况下表现出改善的扩散能力。同时，外泌体由于其生物相容性而作为有效递送生物治疗药物的潜在工具而受到关注。然而，外泌体的临床应用因其有限的趋向性而受到限制。先前获得的纳米马达用于递送外泌体，大大增强了其靶向性。药物阿霉素（DOX）随后被封装在外泌体中，作为代表性的药物模型。在肿瘤部位H2O2浓度条件下，外泌体进入乳腺癌细胞的速度显着增强。外泌体纳米马达的利用为开发混合化学和磁响应纳米马达提供了一种新方法。