Porphyrin-based covalent organic frameworks (Por-COFs) show great promise in photodynamic sterilization and elimination of pathogenic bacteria. In this work, a two-dimensional Por-COF was constructed using 5,10,15,20-Tetrakis-(4-aminophenyl)-porphine-Zn(II) (Zn-TAPP) and Dihydroxyterephthalaldehyde (Dha), which was post-synthetically modified with silver nanoparticles (Ag NPs). Ag@ZnPor-COF delivered extraordinary photodynamic inactivation performance against and under visible light (99.96 % and 99.75 %, respectively, within 20 min). The localized surface plasmon resonance of the Ag NPs enhanced the absorption of visible light whilst also aiding electron-hole separation, leading to efficient generation of reactive oxygen species (ROS), especially singlet oxygen (O). Further, the Ag NPs imparted Ag@ZnPor-COF with photothermal properties, thereby delivering even more effective control of pathogenic bacteria. Density functional theory (DFT) calculations validated the experimental findings, identifying Ag@ZnPor-COF as a potent antibacterial platform. Results encourage the wider use of Por-COFs and plasmonic nanomaterials in the development of antibacterial systems.

中文翻译：

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锌卟啉共价有机框架锚定银纳米颗粒用于协同光动力灭菌


基于卟啉的共价有机框架（Por-COF）在光动力灭菌和消除病原菌方面显示出巨大的前景。在这项工作中，使用 5,10,15,20-四-(4-氨基苯基)-卟啉-Zn(II) (Zn-TAPP) 和二羟基对苯二甲醛 (Dha) 构建了二维 Por-COF， -用银纳米颗粒（Ag NPs）进行合成修饰。 Ag@ZnPor-COF 在可见光下和在可见光下具有非凡的光动力失活性能（20 分钟内分别为 99.96% 和 99.75%）。 Ag NP 的局域表面等离子体共振增强了可见光的吸收，同时也有助于电子-空穴分离，从而有效产生活性氧 (ROS)，尤其是单线态氧 (O)。此外，Ag NPs 赋予 Ag@ZnPor-COF 光热特性，从而更有效地控制病原菌。密度泛函理论 (DFT) 计算验证了实验结果，将 Ag@ZnPor-COF 确定为有效的抗菌平台。结果鼓励在抗菌系统的开发中更广泛地使用 Por-COF 和等离子体纳米材料。