Currently, methicillin‐resistant Staphylococcus aureus (MRSA)‐induced osteomyelitis is a clinically life‐threatening disease, however, long‐term antibiotic treatment can lead to bacterial resistance, posing a huge challenge to treatment and public health. In this study, glucose‐derived carbon spheres loaded with zinc oxide (ZnO@HTCS) are successfully constructed. This composite demonstrates the robust ability to generate reactive oxygen species (ROS) under ultrasound (US) irradiation, eradicating 99.788% ± 0.087% of MRSA within 15 min and effectively treating MRSA‐induced osteomyelitis infection. Piezoelectric force microscopy tests and finite element method simulations reveal that the ZnO@HTCS composite exhibits superior piezoelectric catalytic performance compared to pure ZnO, making it a unique piezoelectric sonosensitizer. Density functional theory calculations reveal that the formation of a Mott–Schottky heterojunction and an internal piezoelectric field within the interface accelerates the electron transfer and the separation of electron–hole pairs. Concurrently, surface vacancies of the composite enable the adsorption of a greater amount of oxygen, enhancing the piezoelectric catalytic effect and generating a substantial quantity of ROS. This work not only presents a promising approach for augmenting piezoelectric catalysis through construction of a Schottky heterojunction interface but also provides a novel, efficient therapeutic strategy for treating osteomyelitis.

中文翻译：

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超声触发压电催化氧化锌@葡萄糖衍生碳球治疗 MRSA 感染的骨髓炎


目前，耐甲氧西林金黄色葡萄球菌（MRSA）引起的骨髓炎是临床上危及生命的疾病，但长期抗生素治疗会导致细菌产生耐药性，给治疗和公共卫生带来巨大挑战。在这项研究中，成功​​构建了负载氧化锌的葡萄糖衍生碳球（ZnO@HTCS）。该复合材料表现出在超声波 (US) 照射下产生活性氧 (ROS) 的强大能力，可在 15 分钟内根除 99.788% ± 0.087% 的 MRSA，并有效治疗 MRSA 引起的骨髓炎感染。压电力显微镜测试和有限元方法模拟表明，ZnO@HTCS复合材料与纯ZnO相比表现出优异的压电催化性能，使其成为一种独特的压电声敏剂。密度泛函理论计算表明，莫特-肖特基异质结和界面内内部压电场的形成加速了电子转移和电子空穴对的分离。同时，复合材料的表面空位能够吸附更多的氧气，增强压电催化效应并产生大量的ROS。这项工作不仅提出了一种通过构建肖特基异质结界面增强压电催化的有前途的方法，而且还为治疗骨髓炎提供了一种新颖、有效的治疗策略。