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Antibodies expand the scope of angiotensin receptor pharmacology Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-14 Meredith A. Skiba, Sarah M. Sterling, Shaun Rawson, Shuhao Zhang, Huixin Xu, Haoran Jiang, Genevieve R. Nemeth, Morgan S. A. Gilman, Joseph D. Hurley, Pengxiang Shen, Dean P. Staus, Jihee Kim, Conor McMahon, Maria K. Lehtinen, Howard A. Rockman, Patrick Barth, Laura M. Wingler, Andrew C. Kruse
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The β-subunit of tryptophan synthase is a latent tyrosine synthase Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-14 Patrick J. Almhjell, Kadina E. Johnston, Nicholas J. Porter, Jennifer L. Kennemur, Vignesh C. Bhethanabotla, Julie Ducharme, Frances H. Arnold
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A milestone method to make natural killer T cells Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-14 Leonid S. Metelitsa
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Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-14 Yan-Ruide Li, Yang Zhou, Jiaji Yu, Yu Jeong Kim, Miao Li, Derek Lee, Kuangyi Zhou, Yuning Chen, Yichen Zhu, Yu-Chen Wang, Zhe Li, Yanqi Yu, Zachary Spencer Dunn, Wenbin Guo, Xinjian Cen, Tiffany Husman, Aarushi Bajpai, Adam Kramer, Matthew Wilson, Ying Fang, Jie Huang, Shuo Li, Yonggang Zhou, Yuchong Zhang, Zoe Hahn, Enbo Zhu, Feiyang Ma, Calvin Pan, Aldons J. Lusis, Jin J. Zhou, Christopher S. Seet
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Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-14 Taiasean Wu, Joshua C. Yu, Arundhati Suresh, Zachary J. Gale-Day, Matthew G. Alteen, Amanda S. Woo, Zoe Millbern, Oleta T. Johnson, Emma C. Carroll, Carrie L. Partch, Denis Fourches, Nelson R. Vinueza, David J. Vocadlo, Jason E. Gestwicki
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Linking CRISPR–Cas9 double-strand break profiles to gene editing precision with BreakTag Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-13 Gabriel M. C. Longo, Sergi Sayols, Andriana G. Kotini, Sabine Heinen, Martin M. Möckel, Petra Beli, Vassilis Roukos
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Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Singh, Anil Kumar, Upadhyay, Vishal, Sethi, Arppita, Chowdhury, Sangita, Mishra, Shivkant, Verma, Shailendra Prasad, Bhatt, Madan Lal Brahma, Trivedi, Arun Kumar
E3 ubiquitin ligase, ring finger protein 138 (RNF138) is involved in several biological processes; however, its role in myeloid differentiation or tumorigenesis remains unclear. RNAseq data from TNMplot showed that RNF138 mRNA levels are highly elevated in acute myeloid leukemia (AML) bone marrow samples as compared with bone marrow of normal volunteers. Here, we show that RNF138 serves as an E3 ligase
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RNA-based programmable DNA cleavage Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-10 Madeleine B. King, Audrone Lapinaite
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Epigenetic mechanisms linking early-life adversities and mental health Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Cánepa, Eduardo T., Berardino, Bruno G.
Early-life adversities, whether prenatal or postnatal exposure, have been linked to adverse mental health outcomes later in life increasing the risk of several psychiatric disorders. Research on its neurobiological consequences demonstrated an association between exposure to adversities and persistent alterations in the structure, function, and connectivity of the brain. Consistent evidence supports
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Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Bugga, Paramesha, Stoner, Michael W., Manning, Janet R., Mushala, Bellina A.S., Bhattarai, Nisha, Sharifi-Sanjani, Maryam, Webster, Bradley R., Thapa, Dharendra, Scott, Iain
GCN5L1, also known as BLOC1S1 and BLOS1, is a small intracellular protein involved in many key biological processes. Over the last decade, GCN5L1 has been implicated in the regulation of protein lysine acetylation, energy metabolism, endo-lysosomal function, and cellular immune pathways. An increasing number of published papers have used commercially-available reagents to interrogate GCN5L1 function
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Correction: The uncharacterized Pseudomonas aeruginosa PA4189 is a novel and efficient aminoacetaldehyde dehydrogenase Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Muñoz-Clares, Arline Fernández-Silva, Ana L. Juárez-Vázquez, Lilian González-Segura, Javier Andrés Juárez-Díaz, Rosario A.
The authors of the original article titled ‘The uncharacterized Pseudomonas aeruginosa PA4189 is a novel and efficient aminoacetaldehyde dehydrogenase’ 10.1042/BCJ20220567 would like to correct Equation 4 on page 277. The equation contained an error in the numerator. The requested correction has been assessed and agreed upon by the Editorial Board. The authors declare that these corrections do not
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Behavioral control through the direct, focal silencing of neuronal activity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-09 Anna V. Elleman, Nikola Milicic, Damian J. Williams, Jane Simko, Christine J. Liu, Allison L. Haynes, David E. Ehrlich, Christopher D. Makinson, J. Du Bois
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Decoding cell replicational age from single-cell ATAC-seq data Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-09
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Tracking single-cell evolution using clock-like chromatin accessibility loci Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-09 Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang, Yi Zhang
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An effective MASH drug is good, but biotech can make it better Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-08
Understanding this complex disease requires better model systems and large-scale data.
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Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-08 Zhe Li, Zhi-min Xu, Wei-peng Chen, Xiao-jing Du, Chun-xian Ou, Zi-kang Luo, Rong Wang, Chu-qing Zhang, Chao-dong Ge, Meng Han, Fudi Wang, Rong-Rong He, Wan-yang Sun, Jun Ma, Xiao-yu Liang, Zhuo-wei Liu
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Stimulating STING for cancer therapy: Taking the extracellular route Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-08 Lingyin Li
Ten years ago, the second messenger cGAMP was discovered as the activator of the anti-cancer STING pathway. The characterization of cGAMP’s paracrine action and dominant extracellular hydrolase ENPP1 cemented cGAMP as an intercellular immunotransmitter that coordinates the innate and adaptive immune systems to fight cancer. In this Perspective, I look back at a decade of discovery of extracellular
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Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-06
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Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-07 Rémy Pétremand, Johanna Chiffelle, Sara Bobisse, Marta A. S. Perez, Julien Schmidt, Marion Arnaud, David Barras, Maria Lozano-Rabella, Raphael Genolet, Christophe Sauvage, Damien Saugy, Alexandra Michel, Anne-Laure Huguenin-Bergenat, Charlotte Capt, Jonathan S. Moore, Claudio De Vito, S. Intidhar Labidi-Galy, Lana E. Kandalaft, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Giacomo Oliveira, Catherine
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Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-07 Stephan Eckert, Nicola Berner, Karl Kramer, Annika Schneider, Julian Müller, Severin Lechner, Sarah Brajkovic, Amirhossein Sakhteman, Christian Graetz, Jonas Fackler, Michael Dudek, Michael W. Pfaffl, Percy Knolle, Stephanie Wilhelm, Bernhard Kuster
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Should neurotechnologies go into the sandbox? Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-06 Walter G. Johnson
Emerging neurotechnologies such as brain–computer interfaces bring together components of biotechnology and digital technology, creating a number of different policy issues. These challenges can range from the safety of medical products to privacy issues with collecting and processing data from the human brain. Such different issues may call for different policy responses. For example, in April 2024
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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-03 Hui Yang, Dinshaw J. Patel
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Molecular glues for protein-protein interactions: Progressing toward a new dream Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-02 Markella Konstantinidou, Michelle R. Arkin
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Response to “The perpetual motion machine of AI-generated data and the distraction of ChatGPT as a ‘scientist’” Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-01 William Stafford Noble
Many of Jennifer Listgarten’s arguments are compelling: in particular, that the protein folding problem is an outlier relative to other grand challenges in science, both in terms of the precise way the problem can be stated and performance measured and in terms of the amount of available, high quality data1. However, although existing biological databases tend to be small relative to the compendia
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Designing drugs with reversible activity Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-30 Dario Neri
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Development of supramolecular anticoagulants with on-demand reversibility Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-30 Millicent Dockerill, Daniel J. Ford, Simona Angerani, Imala Alwis, Luke J. Dowman, Jorge Ripoll-Rozada, Rhyll E. Smythe, Joanna S. T. Liu, Pedro José Barbosa Pereira, Shaun P. Jackson, Richard J. Payne, Nicolas Winssinger
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Molecular glues and induced proximity: An evolution of tools and discovery Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-29 Stephanie Anne Robinson, Jennifer Anne Co, Steven Mark Banik
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Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1 Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-27 Seth D. Ludwig, Bunyarit Meksiriporn, Jiacheng Tan, Rakeeb Kureshi, Akhilesh Mishra, Kyle J. Kaeo, Angela Zhu, Georgia Stavrakis, Stephen J. Lee, David J. Schodt, Michael J. Wester, Dhiraj Kumar, Keith A. Lidke, Andrea L. Cox, Helen M. Dooley, Sridhar Nimmagadda, Jamie B. Spangler
No Abstract
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Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-27 Mohammad Reza Zamani, Martin Hadzima, Kristyna Blazkova, Vladimír Šubr, Tereza Ormsby, Javier Celis-Gutierrez, Bernard Malissen, Libor Kostka, Tomáš Etrych, Pavel Šácha, Jan Konvalinka
Immune checkpoint blockade (ICB) using monoclonal antibodies against programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) is the treatment of choice for cancer immunotherapy. However, low tissue permeability, immunogenicity, immune-related adverse effects, and high cost could be possibly improved using alternative approaches. On the other hand, synthetic low-molecular-weight
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Engineering from evolution Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Francesco Zamberlan
Polyketides are a group of natural products with valuable pharmacological activities, biosynthesized by bacterial or fungal megaenzymes called polyketide synthases (PKSs). These are composed of multiple modules in an assembly line, each introducing a specific moiety of the final compound in a stepwise manner. Among them, trans-acyltransferase PKSs have evolved through the recombination of biosynthetic
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Bacteria lose a pep in their step Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Gene Chong
Zhang et al. hypothesized that a structurally similar disaccharide, GlcNAc-1,6-anhydro-MurNAc, could be a minimal moiety that acts as a competitive inhibitor to lipid II and lacks a reducing end for glycan chain elongation. The authors developed a 15-step total synthesis of the disaccharide-pentapeptide unit, called compound 1, and the disaccharide-only compound, 1-deAA. They incubated compound 1 with
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Setting the pace for degrons Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Yiyun Song
Immunomodulatory drugs (IMiDs), including thalidomide, pomalidomide and lenalidomide, act as molecular glues to induce the ubiquitination and degradation of their target proteins (referred to as neosubstrates) by facilitating their direct interaction with cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. Some neosubstrates contain a C2H2 zinc finger motif that is responsible
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Chris A. Brosey, Todd M. Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L. Hura, Darin E. Jones, John A. Tainer
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Analysis and benchmarking of small and large genomic variants across tandem repeats Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-26 Adam C. English, Egor Dolzhenko, Helyaneh Ziaei Jam, Sean K. McKenzie, Nathan D. Olson, Wouter De Coster, Jonghun Park, Bida Gu, Justin Wagner, Michael A. Eberle, Melissa Gymrek, Mark J. P. Chaisson, Justin M. Zook, Fritz J. Sedlazeck
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Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-26 Nataša Tomašević, Fabiola Susanna Emser, Edin Muratspahić, Jasmin Gattringer, Simon Hasinger, Roland Hellinger, Peter Keov, Manuel Felkl, Jürg Gertsch, Christian F.W. Becker, Christian W. Gruber
The cannabinoid-type 2 receptor (CBR), a G protein–coupled receptor, is an important regulator of immune cell function and a promising target to treat chronic inflammation and fibrosis. While CBR is typically targeted by small molecules, including endo-, phyto-, and synthetic cannabinoids, peptides–owing to their size–may offer a different interaction space to facilitate differential interactions with
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Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-26 Chungyu Chang, HyLam Ton-That, Jerzy Osipiuk, Andrzej Joachimiak, Asis Das, Hung Ton-That
The biphasic assembly of Gram-positive pili begins with the covalent polymerization of distinct pilins catalyzed by a pilus-specific sortase, followed by the cell wall anchoring of the resulting polymers mediated by the housekeeping sortase. In , the pilus-specific sortase SrtC2 not only polymerizes FimA pilins to assemble type 2 fimbriae with CafA at the tip, but it can also act as the anchoring sortase
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Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-26 Debarun Patra, Palla Ramprasad, Shivam Sharma, Upalabdha Dey, Vinod Kumar, Satpal Singh, Suman Dasgupta, Aditya Kumar, Kulbhushan Tikoo, Durba Pal
Management of chronic obesity-associated metabolic disorders is a key challenge for biomedical researchers. During chronic obesity, visceral adipose tissue (VAT) undergoes substantial transformation characterized by a unique lipid-rich hypoxic AT microenvironment which plays a crucial role in VAT dysfunction, leading to insulin resistance (IR) and type 2 diabetes. Here, we demonstrate that obese AT
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Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5 J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-26 Miyuki Natsume, Mariko Niwa, Sho Ichikawa, Takuma Okamoto, Hisazumi Tsutsui, Daiki Usukura, Takatsugu Murata, Ryo Abe, Motoyuki Shimonaka, Toshirou Nishida, Isamu Shiina, Yuuki Obata
Normal receptor tyrosine kinases (RTKs) need to reach the plasma membrane (PM) for ligand-induced activation, whereas its cancer-causing mutants can be activated before reaching the PM in organelles, such as the Golgi/-Golgi network (TGN). Inhibitors of protein export from the endoplasmic reticulum (ER), such as brefeldin A (BFA) and 2-methylcoprophilinamide (M-COPA), can suppress the activation of
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Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer’s disease fold J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-26 Pu Duan, Nadia El Mammeri, Mei Hong
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Current advances in photocatalytic proximity labeling Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-24 Steve D. Knutson, Benito F. Buksh, Sean W. Huth, Danielle C. Morgan, David W.C. MacMillan
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Pyro(phospho)mania Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Claire E. Eyers, Christopher J. Clarke
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Minimizing higher-order aggregation maximizes iron mobilization by small molecules Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Andrew D. Blake, Jianhua Chao, Anna M. SantaMaria, Stella Ekaputri, Kelsie J. Green, Samantha T. Brown, Christopher K. Rakowski, Eun-Kyung Choi, Luisa Aring, Peng-Jui Chen, Nicholas M. Snead, Douglas M. Matje, Tao Geng, Angela Octaviani, Keith Bailey, Stanley J. Hollenbach, Timothy M. Fan, Young-Ah Seo, Martin D. Burke
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Extensive protein pyrophosphorylation revealed in human cell lines Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Jeremy A. M. Morgan, Arpita Singh, Leonie Kurz, Michal Nadler-Holly, Max Ruwolt, Shubhra Ganguli, Sheenam Sharma, Martin Penkert, Eberhard Krause, Fan Liu, Rashna Bhandari, Dorothea Fiedler
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Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice Biochem. J. (IF 4.1) Pub Date : 2024-05-08 Baum, Oliver
Knowledge of the primary structure of neuronal NO synthase (nNOS) in skeletal muscle is still conflicting and needs further clarification. To elucidate the expression patterns of nNOS isoforms at both mRNA and protein level, systematic reverse transcription (RT)-PCR and epitope mapping by qualitative immunoblot analysis on skeletal muscle of C57/BL6 mice were performed. The ability of the nNOS isoforms
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A minimum functional form of the Escherichia coli BAM complex constituted by BamADE assembles outer membrane proteins in vitro J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Zhe Wang, Yindi Chu, Qingrong Li, Xiaochen Han, Leyi Zhao, Hanqing Zhang, Kun Cai, Xuyan Zhang, Xingyuan Wang, Youcai Qin, Enguo Fan
The biogenesis of outer membrane proteins is mediated by the -barrel ssembly achinery (BAM), which is a heteropentomeric complex composed of five proteins named BamA-E in . Despite great progress in the BAM structural analysis, the molecular details of BAM-mediated processes as well as the exact function of each BAM component during OMP assembly are still not fully understood. To enable a distinguishment
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The types and numbers of kinesins and dyneins transporting endocytic cargoes modulate their motility and response to tau J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Daniel Beaudet, Christopher L. Berger, Adam G. Hendricks
Organelles and vesicular cargoes are transported by teams of kinesin and dynein motors along microtubules. We isolated endocytic organelles from cells at different stages of maturation and reconstituted their motility along microtubules . We asked how the sets of motors transporting a cargo determine its motility and response to the microtubule-associated protein tau. Here, we find that phagosomes
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Spatial transcriptomics unravels palmitoylation and zonation-dependent gene regulation by AEG-1 in mouse liver J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Alissa Saverino, Xufeng Qu, Rachel G. Mendoza, Suchismita Raha, Debashri Manna, Ali Gawi Ermi, Mark A. Subler, Jolene J. Windle, Jinze Liu, Devanand Sarkar
Obesity-induced metabolic dysfunction-associated steatohepatitis (MASH) leads to hepatocellular carcinoma (HCC). Astrocyte-elevated gene-1/Metadherin (AEG-1/MTDH) plays a key role in promoting MASH and HCC. AEG-1 is palmitoylated at residue cysteine 75 (Cys75) and a knock-in mouse representing mutated Cys75 to serine (AEG-1-C75S) showed activation of MASH- and HCC-promoting gene signature when compared
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Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Huaiyi Zhu, Yunfei You, Boming Yu, Zhitao Deng, Min Liu, Zhenying Hu, Jingjing Duan
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Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Jingwen Pei, Dayuan Zou, Lu Li, Lulu Kang, Minli Sun, Xu Li, Qianyue Chen, Danning Chen, Bin Qu, Xiang Gao, Zhaoyu Lin
Lipid metabolism is important for the maintenance of physiological homeostasis. Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adipocyte-specific KO mice to characterize the role
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The discovery of a catalytic RNA within RNase P and its legacy J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Leif A. Kirsebom, Fenyong Liu, William H. McClain
Sidney Altman's discovery of the processing of one RNA by another RNA that acts like an enzyme was revolutionary in biology and the basis for his sharing the 1989 Nobel Prize in Chemistry with Tom Cech. These breakthrough findings support the key role of RNA in molecular evolution, where replicating RNAs (and similar chemical derivatives) either with or without peptides functioned in protocells during
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Probing RNA structure and dynamics using nanopore and next generation sequencing J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-25 Emma Bose, Shengwei Xiong, Alisha N. Jones
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Structural basis for α-tubulin-specific and modification state-dependent glutamylation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-24 Kishore K. Mahalingan, Danielle A. Grotjahn, Yan Li, Gabriel C. Lander, Elena A. Zehr, Antonina Roll-Mecak
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Molecular recording of calcium signals via calcium-dependent proximity labeling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-24 J. Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Joseph H. Lobel, Wei Wang, Ted M. Dawson, Valina L. Dawson, Ruixuan Gao, Yuh Nung Jan, Helen S. Bateup, Nicholas T. Ingolia
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Repurposing AS1411 for constructing ANM-PROTACs Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-23 Xuekun Fu, Jin Li, Xinxin Chen, Hongzhen Chen, Zhuqian Wang, Fang Qiu, Duoli Xie, Jie Huang, Siran Yue, Chunhao Cao, Yiying Liang, Aiping Lu, Chao Liang
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Addendum: Designing microbial consortia with defined social interactions Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-22 Wentao Kong, James J. Collins, Ting Lu
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Assessing the laboratory performance of AI-generated enzymes Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23
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Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Ziva Moravec, Yue Zhao, Rhianne Voogd, Danielle R. Cook, Seon Kinrot, Benjamin Capra, Haiyan Yang, Brenda Raud, Jiayu Ou, Jiekun Xuan, Teng Wei, Lili Ren, Dandan Hu, Jun Wang, John B.A.G. Haanen, Ton N. Schumacher, Xi Chen, Ely Porter, Wouter Scheper
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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Si-Kun Guo, Chu-Xiao Liu, Yi-Feng Xu, Xiao Wang, Fang Nan, Youkui Huang, Siqi Li, Shan Nan, Ling Li, Edo Kon, Chen Li, Meng-Yuan Wei, Rina Su, Jia Wei, Shiguang Peng, Nitay Ad-El, Jiaquan Liu, Dan Peer, Ting Chen, Li Yang, Ling-Ling Chen
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Computational scoring and experimental evaluation of enzymes generated by neural networks Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Sean R. Johnson, Xiaozhi Fu, Sandra Viknander, Clara Goldin, Sarah Monaco, Aleksej Zelezniak, Kevin K. Yang