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Toward a Chemical Constructor: A Lego-Like Approach for Formal α-Alkylation of Cyclic Ketones J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Andriy I. Frolov, Yaroslav O. Chuchvera, Eugeniy N. Ostapchuk, Tetiana V. Druzhenko, Dmytro M. Volochnyuk, Serhiy V. Ryabukhin
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Silver-Promoted Rapid Synthesis of 3-Arylindan-1-ones: Microwave-Assisted Reductive Coupling of N-Tosylhydrazone and Boronic Acids J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Natarajan Tamizharasan, Pandeeswaran Santhoshkumar, Nainamalai Devarajan, Mahanandeesha S. Hallur, Gurulingappa Hallur, Palaniswamy Suresh
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DFT Calculations Rationalize Unconventional Regioselectivity in PdII-Catalyzed Defluorinative Alkylation of gem-Difluorocyclopropanes with Hydrazones J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Aili Feng, Yiying Yang, Chengbu Liu, Dongju Zhang
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Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3H-spiro[benzofuran-2,4′-piperidine] Building Block J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Matthew M. Pompeo, Sean M. Kelly, Frédéric St-Jean, Thomas M. Bass, Derek M. Dalton, Daniel Zell, Chong Han, Lauren E. Sirois, Francis Gosselin
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Nucleobase-Coupled Xanthones with Anti-ROS Effects from Marine-Derived Fungus Aspergillus sydowii J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Rui Ge, Xingchen Guo, Hongli Jia, Jing Zhang, Aili Fan, Dong Liu, Jian Huang, Wenhan Lin
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Ligand-Enabled C6-Selective C–H Arylation of Pyrrolo[2,3-d] Pyrimidine Derivatives with Pd Catalysts: An Approach to the Synthesis of EGFR Inhibitor AEE-788 J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Min Liu, Baojie Qiu, Zhuo Zhang, Yulong Zheng, Junyu Yuan, Hailing Li, Xingxian Zhang
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Patumantanes A–D, seco-Polycyclic Polyprenylated Acylphloroglucinols with Diverse Carbon Skeletons from Hypericum patulum J. Org. Chem. (IF 3.6) Pub Date : 2024-05-20 Yulin Duan, Bo Tao, Zhengyi Shi, Yi Guo, Yeting Zhang, Yu Zou, Changxing Qi, Yonghui Zhang
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Visible-Light-Triggered Synthesis of N-α-Ketoacylated Sulfoximines by Denitrogenative and Oxidative Functionalization of Vinyl Azides J. Org. Chem. (IF 3.6) Pub Date : 2024-05-17 Subhankar Sarkar, Satyajit Pal, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
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Regioselective N-Trideuteromethylation of Tautomeric Polyaza Heterocycles J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Jianxin Zhang, Bowen Lei, Mingrui Qin, Tao Lei, Ge Yang, Junjie Liu, Qianhui Liu, Da-Jin Yang, Shu-Feng Song, Yudong Yang
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Regioselective Cobalt(II) Catalyzed C–H Functionalization and [3 + 2] Annulation of N-Arylguanidines with 1,3-Diynes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 Harish Parihar, Pooja Yadav, Natesan Thirupathi
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A Mechanistic Investigation of the N-Hydroxyphthalimide Catalyzed Benzylic Oxidation Mediated by Sodium Chlorite J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 Thomas Grunshaw, Susanna H. Wood, Stephen Sproules, Andrew Parrott, Alison Nordon, Peter D. P. Shapland, Katherine M. P. Wheelhouse, Nicholas C. O. Tomkinson
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Organocatalyzed Photoelectrochemistry for the Generation of Acyl and Phosphoryl Radicals through Hydrogen Atom-Transfer Process J. Org. Chem. (IF 3.6) Pub Date : 2024-05-18 Hong He, Cai-Mi Pan, Zhong-Wei Hou, Manman Sun, Lei Wang
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Cascade [4 + 1] Annulation through Activation of the C(sp2)–H Bond Enabling Benzothiadiazinoisoindolcarboxylate, Benzothiadiazinoisoindole, and Benzothiadiazinoisoindolepyrrolidinedione as Hybrid Spiro-Heterocyclic Frameworks† J. Org. Chem. (IF 3.6) Pub Date : 2024-05-17 Anindita Sarkar, Rahul Dev Mandal, Nirnita Chakraborty, Asish R. Das
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Dearomative [2 + 1] Spiroannulation of Bromophenols with Electron-Deficient Alkenes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-17 Ting-Ting Yang, Yun-Qiao Zhang, Ming-Sheng Xie, Yin Tian, Dong-Chao Wang, Hai-Ming Guo
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Electrochemical Oxidative 1,2-Dithiocyanation: Access to Functionalized Alkenes and Alkynes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-17 Ning Zhang, Zhen Cheng, Yu Xia, Ziren Chen, Fei Xue, Yonghong Zhang, Bin Wang, Shaofeng Wu, Chenjiang Liu
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Expanding the Scope of Group Transfer Radical Reaction: Toward the Synthesis of Fluorinated Nucleoside Analogues Incorporating Difluorophosphonylated Allylic Ether Moieties J. Org. Chem. (IF 3.6) Pub Date : 2024-05-17 Aurore Ceuninck, Thierry Lequeux, Emmanuel Pfund
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Indolo[3,2-a]carbazoles as Engineered Materials for Optoelectronic Applications: Synthesis, Structural Insights, and Computational Screening J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Krishan Kumar, Diksha Thakur, Anirban Karmakar, Subhendu Patra, Arun Kumar, Subrata Banik, Subrata Ghosh
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Copper-Catalyzed Multicomponent Coupling Reaction of Primary Aromatic Amines, Rongalite, and Alkynes: Access to N-Aryl Propargylamines J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Miao Wang, Hui-Ying Ren, Xiao-Lu Zhang, Xiao-Yu Pu, Shan Jiang, Bang-Tun Zhao
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Copper-Catalyzed Decarboxylation Cross-Coupling Cascade Reaction for Synthesis of Fused Dihydro-benzoxazinones J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Weidong Jiang, Zhuo-Huan Li, Tuan-Jie Li, Jian-Quan Liu, Xiang-Shan Wang
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Streamlined Synthesis of Varied Heteroarene-Condensed Benzofuran Derivatives via [4 + 2] Annulation of Benzofuran-Derived Azadienes and N-Alkyl Quinolinium Salts J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Yong-Zheng Lv, Ya-Xin Fan, Ya-Qian Shi, Shan Li, Ji-Yuan Du, Fei Gao, Hong-Li Huang
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Photocatalyzed C3–H Nitrosylation of Imidazo[1,2-a]pyridine under Continuous Flow and External Photocatalyst-, Oxidant-, and Additive-Free Conditions J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Huijie Qiao, Kun Zhao, Xilin Zhu, Xiaoxu Xu, Shixing Wang, Liting Yang, Chunyang Wang, Lulu Zhong, Baiwei Ma, Dehong Yang, Peizhi Xing, Guoqun Liu, Mingli Jiao
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One-Pot Synthesis of Vinylogous Cyano Aminoaryls (VinCAs) as Benzenic Fluorophores: Tailoring Diverse Emission Colors for White Light Emitting Materials and Cell Imaging J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Saurajit Ghosh, Shubham Kumar, Swathi Suneesh, Himanshi Bhambri, Sanjay K. Mandal, Sarbani Ghosh, Rajdeep Chowdhury, Partha Sarathi Addy
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A True Reverse Anomeric Effect Does Exist After All: A Hydrogen Bonding Stereocontrolling Effect in 2-Iminoaldoses J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Esther Matamoros, Esther M. S. Pérez, Mark E. Light, Pedro Cintas, R. Fernando Martínez, Juan C. Palacios
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Surfactant-Dependent Partitioning of Organics in Aqueous–Organic Reaction Systems J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Yiqing Zhang, Suzanne A. Blum
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Divergent Synthesis of Cyclopropanated Tetrahydroquinolines by Tandem Functionalization of Quinoline Derivatives J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Jianjie Chen, Jian Yang, Min Zhang
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Substituent Effects on the Equilibria between Cyclopropylcarbinyl, Bicyclobutonium, Homoallyl, and Cyclobutyl Cations J. Org. Chem. (IF 3.6) Pub Date : 2024-05-16 Sean P. Larmore, Pier Alexandre Champagne
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Copper-Catalyzed [4+1+1] Annulation of Ammonium Salts and Anthranils: Synthesis of 2,3-Diaroylquinolines J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 Jia-Cheng Yang, Cheng-Wei Ma, Mao-Lin Liao, Ping-Gui Li, Liang-Hua Zou
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Ru(II)-Catalyzed C(sp2)–H Activation Annulation: Synthesis of Fluorescent Benzoisoquinolonyl Acetate/Peptides from N-Arylamides and Ethyne at Room Temperature J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 Manish K. Gupta, Ankita Panda, Nagendra K. Sharma
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Sequential Ring Opening/In Situ SO2-Capture/Alkynylation of Cyclopropanols with Alkynyl Triflones Initiated by Energy Transfer J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 Guohua Fan, Changfu Wu, Xiaozu Liu, Peijun Liu
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Tailoring Emission Color Shifts in Mechanofluorochromic-Active AIE Systems of Carbazole-Based D−π–A Conjugates: Impact of π Spacer Unit Variants J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 A. Afrin, P. Chinna Ayya Swamy
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Regioselective Syntheses of 2,3,5-Trisubstituted Pyridines via 5-Chloro-3-fluoro-2-(methylsulfonyl)pyridine J. Org. Chem. (IF 3.6) Pub Date : 2024-05-15 Robert E. Wiley, Martin Holan, Wan Shin Kim, Khoa D. Nguyen, Xingzhong Zeng, Mariusz Krawiec, Andrew T. Brusoe
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Assembly and Disassembly of Supramolecular Hypervalent Iodine Macrocycles via Anion Coordination J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Krishna Pandey, Samsul Arafin, Eli Jones, Yachu Du, Gajanan C. Kulkarni, Ain Uddin, Toby J. Woods, Kyle N. Plunkett
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Pyridinium Ylide-Mediated Diastereoselective Synthesis of Spirocyclopropanyl-pyrazolones via Cascade Michael/Substitution Reaction J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Akanksha Kumari, Dhirajkumar Jitendrabhai Patanvadiya, Anshul Jain, Ranjan Patra, Manikandan Paranjothy, Nirmal K. Rana
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Quasi-Podands with 1,2,3-Triazole Rings from Bile Acid Derivatives: Synthesis, and Spectroscopic and Theoretical Studies J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Anna Kawka, Hanna Koenig, Damian Nowak, Tomasz Pospieszny
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Electrochemical Reductive Cross-Coupling of Alkyl or Alkenyl Halides with gem-Difluoroalkenes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Hong Zhang, Zenghui Ye, Jiyuan Tang, Yanqi Wu, Xi Zhang, Weiyuan Ma, Zhajun Zhan, Fengzhi Zhang
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Palladium-Catalyzed Three-Component Cascade Carbonylation Reaction to Construct Benzofuran Derivatives J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Ming Li, Shanmei Xu, Dong-Ping Chen, Fan Gao, Shun-Xi Li, Shuang-Xi Zhu, Yi-Feng Qiu, Zheng-Jun Quan, Xi-Cun Wang, Yong-Min Liang
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Synthesis of Benzo[e][1,4,3]oxathiazin-3-one 1-Oxides from NH-S-(2-Hydroxyaryl)sulfoximines J. Org. Chem. (IF 3.6) Pub Date : 2024-05-14 Kiruthika Periasamy, Pit van Bonn, Runa Tschekorsky Orloff, Nils Völcker, Qiulan Lu, Kari Rissanen, Carsten Bolm
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Synthesis of N2-trans-isosafrole-dG-adduct Bearing DNAs and the Bypass Studies with Human TLS Polymerases κ and η J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Siddharam Shivappa Bagale, Priyanka U. Deshmukh, Shailesh B. Lad, Akhil Sudarsan, Sruthi Sudhakar, Soumyadeep Mandal, Kiran Kondabagil, P. I. Pradeepkumar
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Synthesis of Perdeuterated Alkyl Amines/Amides with Pt/C as Catalyst under Mild Conditions J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Hong-Hai Zhang, Meng-Zhe Chen, Xinbin Yu, Peter V. Bonnesen, Zili Wu, Hsin-Lung Chen, Hugh O’Neill
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Synthesis of Branch-Type 3-Allylindoles from N-Alkyl-N-cinnamyl-2-ethynylaniline Derivatives Using π–Allylpalladium Chloride Complex as a Catalyst J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Kohei Watanabe, Keita Nakano, Hayato Sato, Toshiki Yamaoka, Yasushi Yoshida, Ryo Takita, Yoshio Kasashima, Masami Sakamoto, Takashi Mino
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Carbene-Catalyzed Atroposelective Construction of Chiral Diaryl Ethers J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Yuheng Liu, Lutong Yuan, Linlong Dai, Qiaohong Zhu, Guofu Zhong, Xiaofei Zeng
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Visible-Light-Promoted Radical Cascade Cyclization of 2-Vinyl Benzimidazoles: Access to Benzo[4,5]imidazo[1,2-b]isoquinolin- 11(6H)-ones J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Yao-Tian Wang, Mai Zhang, Zhi-Xing Liu, Yu-Xin Wu, Qian Yan, Cheng-Liang Liu, Jiang-Sheng Li, Zhi-Wei Li, Han-Wen Liu, Wen-Sheng Li
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ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes J. Org. Chem. (IF 3.6) Pub Date : 2024-05-13 Xuemei Wei, Tao Cai, Zhebing Zhang, Yanjuan Luo, Tianbo Shang, Hualiang Shen, Huiting Xu, Lemao Yu, Xiang Luo, Guoqi Yu, Runpu Shen
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Photoredox Synthesis of Silicon-Containing Isoindolin-1-ones and Deuterated Analogues Through Hydrosilylation and Deuterium-silylation J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Guo-Qin Wang, Yue Zhang, Yuan-Xia Zhou, Dan Yang, Pan Han, Lin-Hai Jing, Kai Tang
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Exploring a Non-Comfort Zone: Central Chirality-Generating Macrocyclizations J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Kuan Zheng, Ran Hong
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An Expedient Approach to Access Phenalenones via Unconventional [1,2]-Phospha-Brook Rearrangement/Carbonyl Migration J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Amjad Ali, Chandana Behera, Ravi P. Singh
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Deoxygenative Hetero- and Carbofunctionalizations of Diarylketones J. Org. Chem. (IF 3.6) Pub Date : 2024-05-10 Moriaki Sakihara, Miki B. Kurosawa, Mizuho Watanabe, Shuhei Shimoyama, Junichiro Yamaguchi
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Substrate-Controlled Divergent Synthesis of Benzimidazole-Fused Quinolines and Spirocyclic Benzimidazole-Fused Isoindoles J. Org. Chem. (IF 3.6) Pub Date : 2024-05-09 Ying-Ti Huang, Wan-Wen Huang, Yi-Ting Huang, Hong-Ren Chen, Indrajeet J. Barve, Chung-Ming Sun
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Self-Aggregation, Enhanced Guest-Binding Behavior, and Anion-Induced Agglutination of Cyclophane Dimers Linked with Florescent Perylene Diimide J. Org. Chem. (IF 3.6) Pub Date : 2024-05-09 Osamu Hayashida, Yuya Araki, Takaaki Miyazaki
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Visible-Light-Promoted C3-Sulfenylindoles with Arylsulfonyl Chlorides via Electron Donor–Acceptor Complex J. Org. Chem. (IF 3.6) Pub Date : 2024-05-09 Ziqian Xue, Wenjing Yang, Qiuzhan Huang, Cong-Ying Zhou, Zhen Guo
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Copper-Catalyzed One-Pot Synthesis of Thiazolidin-2-imines J. Org. Chem. (IF 3.6) Pub Date : 2024-05-09 Leandros P. Zorba, Ioannis Stylianakis, Nikolaos Tsoureas, Antonios Kolocouris, Georgios C. Vougioukalakis
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Rational Design of a Highly Sensitive Carboxylesterase Probe and Its Application in High-Throughput Screening for Uncovering Carboxylesterase Inhibitors J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Kexin Wang, Ruoxi Wang, Zihui Yan, Yi Li, Yangchen Shi, Jing-Yuan Ge, Yang Bai, Zhongyan Chen, Lei Zhang
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Synthesis of 2-(Trifluoromethyl)-[1,2,4]triazolo[5,1-a]isoquinoline via Cycloaddition of C,N-Cyclic Azomethine Imine with CF3CN J. Org. Chem. (IF 3.6) Pub Date : 2024-05-09 Zhezuo Chen, Shouxiong Chen, Zhanyan Qiu, Bo Lin, Yunfei Yao, Fafu Yang, Zhiqiang Weng
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Copper/O2-Mediated Oxidative C–C Activation of Nitriles for Selective Acylation-Bromination of Anilines J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Wei-Yu Shi, Song-Lin Zhang
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Lewis Acid-Catalyzed Formal [4 + 2] Reaction of Alkynyl Sulfides and 2-Pyrones To Access Polysubstituted Aryl Sulfides J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Bin Huang, Donghui Xing, Huanfeng Jiang, Liangbin Huang
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Pd-Catalyzed Miyaura Borylation and Telescopic Borylation/Suzuki–Miyaura Cross-Coupling Processes in Deep-Eutectic Solvents J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Francesco D’Amico, Costanza Papucci, Daniele Franchi, Gianna Reginato, Maurizio Taddei, Alessandro Mordini, Lorenzo Zani, Alessio Dessì, Massimo Calamante
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Effective In Situ Alkoxide Trapping by TMSX in the Presence of TPP Catalyst in Glycidol Acetal Rearrangements J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Meera Johny, Goreti Rajendar
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α-Cleavage of 2,2-Diazido-2,3-dihydroinden-1-one in Solution and Cryogenic Matrices J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Brandi James, H. Dushanee M. Sriyarathne, Upasana Banerjee, Wandana K. S. Henarath Mohottige, Ben Crabtree, Aliz León, Miao Hong, Javeria Tariq, Taha Alhayani, Manabu Abe, Bruce S. Ault, Anna D. Gudmundsdottir
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Purple Light-Promoted Coupling of Bromopyridines with Grignard Reagents via SET J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Xingyu Lei, Yihan Wang, Shanshan Ma, Peng Jiao
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Flexible and Convergent Enantioselective Total Synthesis of (R)-Juglanaloids A and B: Two Phthalide Spiro Alkaloids with Potential Alzheimer’s Disease Inhibitory Activity J. Org. Chem. (IF 3.6) Pub Date : 2024-05-08 Ibrahim Khettar, Arianna Sinibaldi, Rosaria Schettini, Giorgio Gorini, Ayesha Siddiqa, Antonella Dentoni Litta, Francesco De Riccardis, Irene Izzo, Giorgio Della Sala